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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222849bfdc3b059a8636c3f375769e9815c90969bcb97ed2c46ea2eb9ed64005' 
  AND token = 'GCQAwcqwgUAVS2yiACtByFCiFq76iW+hkUkWi6puTwQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}