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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8ea81ac3078c9c65913b3c308c07f97d37eedb80d1950dca56541d017ef3382' 
  AND token = '/+29+MrmY+MuNPuK7fre5rPu1xM5DtlS2s9TFLYZrQE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}