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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '414762896143b137776292ade4d544c519359186534affc6a7ccac23d0ccfd22' 
  AND token = '337+cNseoNICVDshX6aLwZRO+QPg8FI18e7hO5nvztM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}