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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '757fad860d6e7e5cd3d2a9ec0050036bc2455c5dd6b1e0c7180219b354ce9c9c' 
  AND token = 'f3zKzmhJtCnz8lkrMizrVNPh6aLwSKFmpugFcOOeSDY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}