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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21f7aafaa660d003fe57e7882f4e63428389244355e465859b18a48063fb808c' 
  AND token = '+7IpVp74YT4FrgK8Rwh8f0N3LRjoB/l4wEHeHdFPxRM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}