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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ebf2a7d2294bce2c2098a780bf3f3b448ed470ec1b8e17eebbd9273160e08e44' 
  AND token = 'i2/NZrKBiljQqrQJhesF7VfY9lnXtaPvw7r6sERw3bE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}