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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4b288e9fffdc3ea3861e9ddbc71c95d0cbb74487149c865bdec97c0b8209596' 
  AND token = '1+N6eg0nE+GrWzOtpUTRrLNQALLzJ3UtLV23xiMqMZ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}