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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66808a7d0c3fd5fa3619afc305a8541cd357c3d869125607dcf38f4ee64cb243' 
  AND token = 'Iu8hlbg4QQTs0zC0Up9t8SA7iN4Jf1KZYfnrM93PT8I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}