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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '650a1dffca6a5cf989d2c5d3f497e34682cecb30a7764afa850b6ee4ae363a4d' 
  AND token = 'IGxvPN60pCOQg3dG29Y1zkFa4k9mnImrNkg9X8Exz/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}