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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2443b1ca3f839b34e5812953e7cba9c0a4ddcdb115c3656302f39e7421039280' 
  AND token = 'OkiAVDb+HZtiMwxsYxF01sntNv72jWRisEd3t+n6xSY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}