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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '47e2c055b87f3a322bd61a071edc8fe68440c2178507e1fb424bdaeb1cd18111' 
  AND token = 'TpAaOGK5tnvW7vBkmkXfbfyxU6lZcArkXeAUqmJb/9A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}