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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '681458c45936887cc5b2b1f8dad41876d4402b852d472f95de4f9d6c5db62cf9' 
  AND token = '4YAqYT5IxJ0kOfNonX+q4N9qUjPEtJLcFnEqTAC8xsI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}