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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a22255947e26bcebad929c39a343bb746f28038338b838b533de79c2fe0b76f' 
  AND token = '2kCVVFjGCMGlMg8afUmft0R7sm1px8294rOY1z2kvhA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}