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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c452040680106b5a22ec802d38f5e3a23528d2c4af76ec7b58a5e3e3affab785' 
  AND token = 'kPDkrKdEby1GXBYOm3G9gB7/9yTpcsIVWevWCK+cBGE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}