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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '90789cc452d16f8fff5cb7d50c7f16fd3d642c87964ffcd02e06666974163c33' 
  AND token = 'mNaBWUd47SO9lOR1WGHu/rFolY+NMF/UBLjpBbGxFi4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}