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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce563e7234c299ed6680bd28fd3538ad3d3b9dc36a2b628109cb8b0cd5971efe' 
  AND token = 'vT7I+EF16T8NSUpnjTN5IYp3HQ04k5FY2N/5MJg1gS0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}