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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5414c0c8050a2987fa0491ec8c65d061c81d204c675d83372aa97a9456a90d8a' 
  AND token = 'hwA9JhRBkZlvo/fVypNNV9Q387UxUJt1bO0As+QSs9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}