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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a650ada24564d11ff9e32b4fbb26a2aa726fc265fbd831a7a42f0bd3b6ba440' 
  AND token = 'azEdQ+SpMfMr0u3MioQ933Pz6vw7Uq0wx9mga4wMvQc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}