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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4229fcff9206bbaeaa805a2a75defbaa68a2a907d7df8b8be77d4d0ed749d456' 
  AND token = '5O2meD3Cyf/kT8JB+7WdEwOEDpG8NAjRVFGbAWS4NRY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}