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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8225c65d8e81b28f3fc2c7995fcc7b779912b87340222339a08c006c018a2c6a' 
  AND token = 'jroArAr4EMudiPELFmnmGUfv/AV3wLe/gO+sVDbldUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}