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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21b189ffd411b1a0aaed01adf5e6fc7ca215c16230b5f1446a4f274b2291e328' 
  AND token = '2iwT2pgN903zw/mSb4/YYqGxcYxEEJhC8qONKUVzcng=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}