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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e221fadb1bd184c6f074165939f180858c4e977918f4c2e48b9aa7d00197ff1' 
  AND token = 'kBBaFY5c+3SMzHAxh1W5EXOcWyp87xHZRShcUaqJzq0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}