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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a56295fa0019bb353fb5e56b9f253e0ab8fc2a180bf3d154da642799d206e7dc' 
  AND token = 'XEQ/sEeXEVyc4vcHxYJDtxm5Kodo64N+IXMtnJkfP0E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}