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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0094e62dae4008e8d94a2a4bae6993cde158edb04f8b9ea931d947623688622' 
  AND token = 'FV0EWzrnT+e/FiqZZUTlikrRvq1uSM74Qksa+qPi+Lc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}