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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '252cb46a996b86694213087f728773a7902e0aeec5479d1c4e29c6c66642eade' 
  AND token = 'XS2rmizryynSKfhsVWVKG/z46A+s14exTOArrAB7PA8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}