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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1465592817ba4d98a0b2fe9475a4400131e17dbf97ac56f5d75b388a3eedf4bf' 
  AND token = 'NgpT/FMktcSSr08WMUQjxuvAMWtQZhTdbx7H6E8Bmcc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}