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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01cd18ae4f4d865b2ffeb79e40e1d144480f5e4fc864f7653ab34aed56f78443' 
  AND token = 'MlSofDJDV0RGNH45J23/8lliP/ck5Bbm546YTZtQ9rg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}