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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef99a224ca4003d9e14612d84c53a5a0b94de70f270dc876a1d8d32e923c45aa' 
  AND token = 'cpiuMERZDXp8K3BOJbnK6wc1CbBG4RvEP0yQFcgTdpU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}