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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649efce4b637c6a18e4940000f1306c920529db43eeed514fc8ec047d934d765' 
  AND token = '1qVPtHKQPv7fG4A7n/vncVitU9101vORielRu+qH3pQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}