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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a36dd6c2a42d27aa73702f5bb7f8423008b48372e6dcb6730f2ef9327f7a81d' 
  AND token = 'yiK+z5pDBUM4i1KlzhEaH4AkgPMHhUEU0JQiJHWji3Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}