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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c181e76f9ce2ceabad33f7e580eba2e6e35355599ac84ed5577abd1dc2dcc274' 
  AND token = 'ZbqvgdcMEVKITTanRj8Shv6DkjnH+JW7KNk4f4iCa74=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}