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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c03be68d5c133c2e9436f97bcefe2ea45ecde8e3a2b0205a066905cdb195ef' 
  AND token = 'UP8t0ggoikMMQ6KmrE8rN+uxSbrX+H2D5nPCDuBa65U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}