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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a50d00601ef54aab799787e0378736635e0fa14bd171b876f1bacd0c4004fb6' 
  AND token = 'bLVeKZM+9j9g1DHK9DfTCUMgnsQXvnf9mtFU/byLWMk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}