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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4543ee6df17488250f8b4b9082c7b0f5a53fb64f9980de176af09be670b78fe4' 
  AND token = 'QRt2q5+F3FiUgZUFLqW2TDzoZCPxXKr60md7p24BGA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}