SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22160699b69e4780a451fbaf020c3e16bcc27b502d77bb8c7284d6f477524310' 
  AND token = 'VONqRu9ZLyxSNKHU5K1CPfgPpvF/xM8sa+cggjAAxbs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}