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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c2241561c395832ef757b39de8dd24da6581b9b8de6e43b8d14b1bbbe3f08444' 
  AND token = 'O1Eo+skXG9lXUn80Wfw3zNUx4Uk3WC8LvrZ9yU52obs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}