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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b0081b03e7706c921bfa45a60dd360b01e6193a943d3d9095dacb120168c920e' 
  AND token = 'U2EnM0FEaR1OXP/984NfVxT4SVDEJgvArqM71xO1NEU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}