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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a66dc1e8401fff4d4102ce055b90b10e0aa3ba3603514a347349a1f78a651251' 
  AND token = 'VYSVQ9dXCERh37Qf/hw/SqMyxYAHbQXwqM1B0dd9wRQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}