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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d31be68fe7731088d0afebf67f157e2a5009fb90402402f63d10d0e5d0e74f0' 
  AND token = 'E32OaQnIij0otT2gng+Ph4Kvk0L9ZXP0IwbMHEN1aJs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}