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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '549e57afb4b4023d3304a4003d465b759e0d3ac0a0b4f36865364fc03acb231d' 
  AND token = 'GOFsZOFnemr/p5Qawpg4eHB4eIDm1+Fe4mVyaly4gsI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}