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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b621c61d6689d1411dc9b0f0cc59095d7ee35e1b5603c1decfe29a76f780905' 
  AND token = 'HZlVBNd7SnlvS9TF90OndlFRsDVuiLzt+KwXZZSRU7I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}