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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '03726af72925a6652833895389f9ae3b0cb1a4cf6199200f4358904aa0760997' 
  AND token = 'PoTpNSms7HEvd5gZRGLIVFqXTJ/7HPWC4LEfdtXQQ1k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}