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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '393a9f0d6020e4db490a57082fbecd636b8d58781d1be1c59b23fabf1d4bfa0a' 
  AND token = 'UpkystTDGY8S0a1bdLiJ2LlPpLzWfL9dSPkSOotOj1o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}