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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ed2177818d2be12f223a02d5025c53fe7f248610d83b0a2785452c44488c1c0' 
  AND token = '+iANFxR3213uCGCTm45hhiXDxblqDQbMZzW5BNinER0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}