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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48e2225e6fdc3b31445c23887c0e204b8a191444c4879b7ce8188c4a2f8faf30' 
  AND token = 'VMNQP4TDyriP5QBelyFhFulggw2oiZdtA1QkBMZh+bI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}