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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '453b06e95558ee698e02fdb00a7989124e206b26cf05d1ae05a5651d96e0d8aa' 
  AND token = 'niBMhb+Jz3wdmLel/d7XlL9YG2Ed2fzblXfhKo+W1jE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}