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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45f671b92f93f58b947ee9eca4b61cf58e73e086d5a8acc95c7e80335f5c94e5' 
  AND token = 'Z5OKVmzy88SiMe9a5/cX2bncR5+AsHAXmUwlDWq9jSg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}