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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9563240982d943cd817ee4b827d6ec870f8e9977ebe8669f5e5e85784ce9b7b2' 
  AND token = 'V+A2ldsUth3zGfWKjBih65tJqJ8rWw93UQP2ul67lJQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}