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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aea95ab320b5d83347a130b99040cc0c7e5e21d5bc5e2faaf9dc180baa08ea72' 
  AND token = 'X4G0fLYMJbhUOm/s2NVGuMgYMVwGghUEDf2MRQDB3dg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}