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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2436e7c4c2423f863bad45f97217cbc00c356a8537257da1c0e0fb7727e57f4' 
  AND token = 'UjO3eLmNt1u8+8lZAmzESNNzbZDbWRpQ+V/2xXg8fBc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}